Malleable putty and flowable paste with allograft bone having residual calcium for filling bone defects

A sterile malleable bone composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing mixture of partially demineralized lyophilized allograft bone powder having a residual calcium content ranging from about 4% to about 8% with a particle size ranging from about 100 to about 800 microns in a sodium hyaluronate with an ionic salt based phosphate buffer carrier causing the composition to have a pH ranging between about 6.8 and about 7.4, the sodium hyaluronate component having a molecular weight of at least seven hundred Daltons and a stable viscosity ranging from 6,000 to about 275,000 cps at 22° to 37° C., the bone content of the carrier ranging in weight from about 20% to less than 50% total weight of the composition.

A sterile malleable bone putty composition for application to a bone defect site to promote new bone growth at the site comprising a new bone growth inducing partially demineralized lyophilized allograft bone powder with a residual calcium content of about 4% to 5% and a particle size ranging from about 100 to about 800 microns in a high molecular weight sodium hyaluronate and saline phosphate buffer carrier, the bone content of the composition ranging from about 30% to about 35% by weight with the sodium hyaluronate component constituting a percentage of the carrier not in excess of 5% and has a molecular weight greater than 700,000 Daltons.

A sterile malleable bone gel composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing amount of partially demineralized lyophilized allograft bone material with a residual calcium content of above 4% to about 6% dry weight and a particle size ranging from about 100 to about 800 microns in a high molecular weight sodium hyaluronate having a molecular weight of at least about seven hundred thousand Daltons in saline phosphate buffer carrier with the sodium hyaluronate component comprising about 1.0% to about 4.0% of the carrier and having a viscosity of about 1,800 to 13,000 cps, the bone powder content of the composition ranging from about 25% to about 30% with said composition having an osmolality ranging from about 280 to about 340 mOsmol/Kg.

A sterile malleable bone putty composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing compound of partially demineralized lyophilized allograft bone material with a calcium content greater than 4% and less than 8% dry weight and a particle size ranging from about 100 to about 800 microns in a hydrogel ionic salt based phosphate buffer carrier, a hydrogel component comprising a glycosaminoglycan ranging from about 2.0% to about 5.0% by weight of the carrier and having a molecular weight of at least 700,000 Daltons.

A sterile malleable bone putty composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing amount of partially demineralized lyophilized allograft bone powder having a residual calcium content of about 4% dry weight in a high molecular weight hydrogel in saline phosphate buffer solution carrier, said hydrogel comprising a glycosaminoglycan having a molecular weight of at least 700,000 Daltons, the bone amount content of the composition ranging from about 27% to about 33% by weight and the high molecular weight hydrogel ranges from about 2.0% to about 5.0% by weight of the carrier, said composition having an osmolality ranging from 280-340 mOsmol/Kg.

A sterile malleable bone putty composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing mixture of partially demineralized lyophilized allograft bone powder having a residual calcium content ranging from greater than 4% to about 8% with a particle size ranging from about 100 to about 800 microns in a hydrogel with an ionic salt based phosphate buffer carrier causing the composition to have a pH ranging between about 7.2 and about 7.4, said hydrogel comprising a polysaccharide selected from the group consisting of sodium hyaluronate, chitosan, sodium alginate, carboxymethylcellulose and hydroxypropylmethylcellulose, said hydrogel component having a molecular weight of at least twenty thousand Daltons and a stable viscosity ranging from 6,000 to about 275,000 cps at 22° to 37° C., the bone content of the carrier ranging in weight from about 20% to less than 50% total weight of the composition.

A sterile malleable bone composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing amount of partially demineralized lyophilized human allograft bone material having a residual calcium content of at least 4% to about 8% in a high molecular weight hydrogel and saline phosphate buffer solution carrier, said hydrogel comprising a sodium hyaluronate or its derivatives having a molecular weight of at least 3,000,000 Daltons, the bone amount content of the composition ranging from about 25% to about 35% by weight and the high molecular weight hydrogel ranging from about 0.25% to about 1.5% by weight of the carrier, said composition having a pH ranging from about 7.2 to about 7.4.

A sterile malleable bone composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing amount of partially demineralized lyophilized human allograft bone material having a residual calcium content of at least 4% to about 8% mixed in a hydrogel and saline solution carrier, said hydrogel selected from a group consisting of chitosan and sodium alginate having a molecular weight ranging from 100,000 to about 300,000 Daltons, the bone amount content of the composition ranging from about 25% to about 50% by weight and the hydrogel ranging from about 1.0% to about 5.0% by weight of the carrier, said composition having a pH ranging from about 7.2 to about 7.4.

A sterile malleable bone composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing amount of demineralized lyophilized human allograft bone material having a residual calcium content of about 4% to about 8% in a hydrogel and saline phosphate buffer solution carrier, said hydrogel comprising a Dextran having a molecular weight of at least 40,000 Daltons, the bone amount content of the composition ranging from about 25% to about 50% by weight and the hydrogel ranging from about 10.0% to about 20.0% by weight of the carrier, said composition having a pH ranging from about 7.2 to about 7.4.

A sterile malleable bone composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing amount of demineralized lyophilized human allograft bone material having a residual calcium content of about 4% to about 8% in a hydrogel and saline phosphate buffer solution carrier, said hydrogel selected from a group consisting of hydroxypropylmethylcellulose and carboxymethylcellulose having a molecular weight ranging from 20,000 to 100,000 Daltons, the bone amount content of the composition ranging from about 25% to about 35% by weight and the hydrogel ranging from about 4.0% to about 6.0% by weight of the carrier, said composition having a pH ranging from about 7.2 to about 7.4.

A sterile malleable bone putty composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing compound of partially demineralized lyophilized allograft bone material with a calcium content greater than 4% and less than 8% dry weight and a particle size ranging from about 100 to about 800 microns in a gelatin ionic salt based phosphate buffer carrier, the gelatin ranging from about 4.0% to about 6.0% by weight of the carrier.

A sterile malleable bone putty composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing compound of partially demineralized lyophilized allograft bone material with a calcium content greater than 4% and less than 8% dry weight and a particle size ranging from about 100 to about 800 microns in a collagen ionic salt based phosphate buffer carrier, the collagen being about 4.0% by weight of the carrier.

A sterile malleable bone putty composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing compound of partially demineralized lyophilized allograft bone material with a calcium content greater than 4% and less than 8% dry weight and a particle size ranging from about 100 to about 800 microns in a gelatin and collagen ionic salt based phosphate buffer carrier, the gelatin being about 6.0% by weight of the carrier and the collagen being about 4.0% by weight of the carrier.

A sterile malleable bone putty composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing compound of partially demineralized lyophilized allograft bone material with a calcium content greater than 4% and less than 8% dry weight and a bone component particle size ranging from about 100 to about 800 microns to achieve a bone concentration ranging from about 25% to about 33% (w/w) in a gelatin and collagen ionic salt based phosphate buffer carrier, the combined weight of the gelatin and the collagen being about 10.0% by weight of the carrier.