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US 6,908,619 B1Granted
Camp factor of streptococcus uberis
AssigneeUniversity of Saskatchewan
InventorsMin Jiang, Andrew A. Potter, Philip Ronald MacLachlan
Life of this patent
Estimating the term…
Abstract
The CAMP factor gene of Streptococcus uberis (S. uberis) is described, as well as the recombinant production of CAMP factor therefrom. CAMP factors can be used in vaccine compositions for the prevention and treatment of bacterial infections.
Claims24
An isolated nucleic acid molecule consisting of a sequence selected from the group consisting of:
- (a) a sequence encoding an immunogenic polypeptide having at least 90% sequence identity to the contiguous amino acid sequence shown at positions 1 through 256, inclusive, of SEQ ID NO:2;
- and (b) a sequence encoding an immunogenic polypeptide having at least 90% sequence identity to the contiguous amino acid sequence shown at positions 1-228, inclusive, of SEQ ID NO:5, wherein any sequence variation between the sequence of (a) and the sequence of amino acids shown at positions 1 through 256 of SEQ ID NO:2 is due to a conservative amino acid substitution, and any sequence variation between the sequence of (b) and the sequence of amino acids shown at positions 1-228 is due to a conservative amino acid substitution.
A recombinant vector comprising:
- (a) a nucleic acid molecule encoding an immunogenic polypeptide comprising a sequence selected from the group consisting of:
- (i) a sequence having at least 90% sequence identity to the contiguous amino acid sequence shown at positions 1 through 256, inclusive, of SEQ ID NO:2;
- and (ii) a sequence having at least 90% sequence identity to the contiguous amino acid sequence shown at positions 1-228, inclusive, of SEQ ID NO:5, wherein any sequence variation between the sequence of (i) and the sequence of amino acids shown at positions 1 through 256 of SEQ ID NO:2 is due to a conservative amino acid substitution, and any sequence variation between the sequence of (ii) and the sequence of amino acids shown at positions 1-228 is due to a conservative amino acid substitution;
- and
- (b) control elements that are operably linked to said nucleic acid molecule whereby said coding sequence can be transcribed and translated in a host cell, and at least one of said control elements is heterologous to said coding sequence.
2 more elements
An isolated nucleic acid molecule comprising a sequence selected from the group consisting of:
- (a) a sequence encoding the contiguous amino acid sequence shown at positions 1 through 256, inclusive, of SEQ ID NO:2;
- and (b) a sequence encoding the contiguous amino acid sequence shown at positions 1-228, inclusive, of SEQ ID NO:5.
Dependencies are inferred from the claim text.