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US 6,904,658 B2Granted
Process for forming a porous drug delivery layer
AssigneeElectroformed Stents, Inc.
InventorRichard A. Hines
Life of this patent
Estimating the term…
Abstract
The present invention is directed to a process for forming a drug delivery device by electroplating onto a substrate a porous layer having pores of a controlled size and density and loading a drug into the pores. Preferably the drug delivery device is a gold stent plated with a gold porous layer.
Claims26
A process for forming a drug delivery device comprising:
- providing a substrate;
- and
- electroplating onto said substrate a porous layer having openings connected to pores of a controlled size and nature,
- wherein said electroplating step comprises electroplating a material that is substantially free of the drug to be delivered, and
- wherein the size and nature of said pores is controlled through controlling the current wave form and plating time in said electroplating step.
2 more elements
A process for forming a drug delivery stent comprising:
- providing a mandrel;
- coating said mandrel with a resist;
- exposing portions of said resist to a light pattern so as to form a stent pattern on said mandrel in said resist;
- electroplating a stent having a percent porosity less than 1% on said mandrel;
- electroplating a porous layer having openings connected to pores of a controlled size and nature on said stent;
- and
- removing said resist and said mandrel,
- wherein said electroplating said porous layer step comprises electroplating a material that is substantially free of the drug to be delivered, and
- wherein the size and nature of said pores is controlled through controlling the current wave form and plating time in said electroplating said porous layer step.
6 more elements
A process for forming a drug delivery stent comprising:
- providing a prefabricated stent;
- and
- electroplating a porous layer having openings connected to pores of a controlled size and nature on said stent,
- wherein said electroplating step comprises electroplating a material that is substantially free of the drug to be delivered, and
- wherein the size and nature of said pores is controlled through controlling the current wave form and plating time in said electroplating step.
2 more elements
A process for forming a drug delivery device comprising:
- providing a substrate;
- electroplating onto said substrate a porous layer having pores of a controlled size and nature, wherein said porous layer has a percent porosity greater than about 1%;
- and
- loading a drug into said pores,
- wherein said electroplating step comprises electroplating a material that is substantially free of the drug to be delivered, and
- wherein the size and nature of said pores is controlled through controlling the current wave form and plating time in said electroplating step.
3 more elements
A process for forming an implantable drug delivery device, comprising:
- providing a sacrificial mandrel;
- electroplating a porous layer on said mandrel to produce a vessel on said mandrel;
- creating at least one hole in said vessel to expose a portion of said mandrel;
- dissolving said mandrel;
- loading said vessel with one or more drugs;
- and
- sealing any of said holes.
4 more elements
Dependencies are inferred from the claim text.