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AssigneesTissue Regeneration, Inc., Trustees of Tufts College
InventorsGregory H. Altman, David L. Kaplan, Rebecca L. Horan, David J. Horan
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The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for implantation into a recipient in need thereof. The invention further provides the novel silk-fiber-based matrix which is seeded with pluripotent cells that proliferate and differentiate on the matrix to form a ligament or tendon ex vivo. Also disclosed is a bioengineered ligament comprising the silk-fiber-based matrix seeded with pluripotent cells that proliferate and differentiate on the matrix to form the ligament or tendon. A method for producing a ligament or tendon ex vivo comprising the novel silk-fiber-based matrix is also disclosed.
A silk-fiber-based matrix composition comprising sericin-extracted silkworm fibroin fibers, said fibers being biocompatible and helically organized into fiber bundles, wherein said matrix supports ingrowth of cells around said fibroin fibers and is biodegradable.
A silk-fiber-based matrix comprising helically organized fiber bundles of sericin-extracted biodegradable silkworm fibroin fibers and bone marrow stromal cells attached thereto.
A composition consisting essentially of sericin-extracted silkworm fibroin fibers, said fibers being biodegradable and organized into a matrix being helically organized into fiber bundles and comprising an ultimate tensile strength of greater than 2000N and a linear stiffness of between 100-600N/mm, wherein sericin is completely removed from said fiber.
Dependencies are inferred from the claim text.