Device for reconstituting a therapeutic solution, suspension or dispersion

A syringe type device actuated by a piston and intended to reconstitute a preparation, in solution, in suspension or in dispersion in a liquid, comprising:

• a cartridge constituting the proximal reservoir (13) containing the non-liquid part (14) of the preparation, said cartridge (13) forming part of the body of said syringe and being sealed at one end by a fixed element (27) and at the other end by a piston (29);
• a cartridge constituting a distal reservoir (11) containing liquid part (12) of the preparation, said cartridge forming an injection rod of the piston of the syringe;
• a hollow transfer element (18) located between the two cartridges (11, 13);
• and
• an injection needle (20);
• wherein these elements are all arranged inside a plastic body and there is no physical link between the two said reservoirs (11, 13),
• said device being characterized in that:
• a) said cartridge constituting the proximal reservoir (13) containing the non-liquid part (14) of the preparation is under vacuum;
• b) said cartridge constituting the proximal reservoir (13) is directly in contact with the outlet of the injection needle (20);
• c) said piston (29) is prevented from being pushed in by a locking mechanism (16) on said reservoir (13), said locking mechanism (16) being able to be deactivated;
• d) said cartridges being designed so that the cartridge constituting the distal reservoir (11) containing the liquid part (12) can penetrate into the interior of the body of the syringe, and, provided the locking mechanism (16) is unlocked, into the interior of the cartridge constituting the proximal reservoir (13) containing the non-liquid part (14) of the preparation;
• and
• e) the device includes a mechanism by which, after entry into said piston (29), said hollow transfer element (18) is withdrawn before the injection and the tightness of the cartridge constituting the proximal reservoir (13) is thereby restored.