Cardiac disease treatment and device

A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A–V groove, the device comprising:

• a. a jacket of flexible, elastic material defining a volume between an upper end and a lower end, the jacket adapted to be secured to the heart and adapted to be adjusted on the heart to snugly conform to an external geometry of the heart and permit substantially unimpeded contraction of the heart during systole while maintaining contact with said heart throughout a cardiac cycle;
• and
• b. a delivery source comprising a coating on the jacket for the delivery of one or more therapeutic agents to a target surface of the heart following placement of the jacket on the heart,
• c. said delivery source provided directly on said jacket and positioned on said jacket to oppose an exterior surface of said heart;
• d. said delivery source adapted for passive delivery of said therapeutic agents to said heart.

A method for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A–V groove, the method comprising:

• a. surgically accessing the heart;
• b. applying a treatment device on the heart, the device comprising:
• 1) a jacket of flexible, elastic material defining a volume between an upper end and a lower end, the jacket adapted to be secured to the heart and adapted to be adjusted on the heart to snugly conform to an external geometry of the heart and permit substantially unimpeded contraction of the heart during systole while maintaining contact with said heart throughout a cardiac cycle;
• and
• 2) a delivery source in association with the jacket for placement therewith on the heart and for the delivery of one or more therapeutic agents to a target surface of the heart following placement of the jacket on the heart;
• 3) said delivery source provided directly on said jacket and positioned on said jacket to oppose an epicardial surface of said heart;
• 4) said delivery source adapted for passive delivery of said therapeutic agents to said heart;
• c. securing the treatment device to the heart;
• and
• d. surgically closing access to the heart while leaving the treatment device on the heart.

A method for providing controlled and sustained administration of one or more therapeutic agents effective in treating cardiac disease, the method comprising surgically implanting a sustained therapeutic agent delivery system at a desired location on the heart, the therapeutic agent delivery system comprising:

• a. a jacket of flexible, elastic material defining a volume between an upper end and a lower end, the jacket adapted to be secured to the heart and adapted to be adjusted on the heart to snugly conform to an external geometry of the heart and permit substantially unimpeded contraction of the heart during systole while maintaining contact with said heart throughout a cardiac cycle;
• and
• b. a delivery source in association with the jacket for placement therewith on the heart and for the delivery of one or more therapeutic agents to a target surface of the heart following placement of the jacket on the heart;
• c. said delivery source provided directly on said jacket and positioned on said jacket to oppose an exterior surface of said heart;
• d. said delivery source adapted for passive delivery of said therapeutic agents to said heart.