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US 6,900,338 B1Granted
Scavenger compounds
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorAbdullah Haj-Yehia
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Abstract
The present invention provides novel compounds having scavenging and anti-ROS properties and pharmaceutical composition comprising these compounds for treatment of conditions associated with oxidative stress or free radical injury. The compounds of the invention are of general formula (I).
Claims9
A scavenger compound of the general formula I
- wherein
- X is a 4-10 membered ring;
- R1 and R2 are independently of each other an alkylene or alkenylene wherein said R1, R2 or both may be unsubstituted or substituted by substituents selected from the group consisting of pyrrolyl, imidazolyl, pyrazolyl, thiazolyl, isothiazolyl, oxazolyl, pyrrolidinyl, pyrrolinyl, imidazolidinyl, imidazolinyl, pyrazolidinyl, pyridyl, pyrazinyl, pyridazinyl, indolyl, oxyindolyl, isoindolyl, indazolyl, indolinyl, 7-azaindolyl, isoindazolyl, quinolyl, isoquinolyl, naphthridinyl, cinnolinyl, quinazolinyl, pyridopyridyl, benzoxazinyl, quinoxadinyl, and carbolinyl;
- R3 is carboxy, amido, alkanol, amino, carboxyalcohol, alkanediol, amine alcohol, amine dial, thio or amine carbonyl;
- R4 is null, H or
- n and n′ are, independently, an integer from 0 to 8;
- D is CH2 or NH;
- and
- Z is a 4-10 membered di sulfide ring or R4
- and its salts.
7 more elements
A scavenger compound of the general formula
- wherein
- X is a 4-10 membered ring;
- R1 and R2 are independently of each other an alkylene or alkenylene wherein said R1, R2 or both may be unsubstituted or substituted by substituents selected from the group consisting of pyrrolyl, imidazolyl, pyrazolyl, thiazolyl, isothiazolyl, oxazolyl, pyrrolidinyl, pyrrolinyl, imidazolidinyl, imidazolinyl, pyrazolidinyl, pyridyl, pyrazinyl, pyridazinyl, indolyl, oxyindolyl, isoindolyl, indazolyl, indolinyl, 7-azaindolyl, isoindazolyl, quinolyl, isoquinolyl, naphthridinyl, cinnolinyl, quinazolinyl, pyridopyridyl, benzoxazinyl, quinoxadinyl, and carbolinyl;
- R3 is alkanol, amino, carboxyalcohol, alkanediol, amine alcohol, amine diol, thio or amine carbonyl;
- R4 is null, H or
- n and n′ are, independently, an integer from 0 to 8;
- D is CH2 or NH;
- and
- Z is a 4-10 membered di sulfide ring or R4and its salts.
6 more elements
Dependencies are inferred from the claim text.