Cobalt-porphyrin complexes and use thereof as an anti-obesity agent
AssigneeMitoKor
InventorsTomas R. Szabo, Soumitra S. Ghosh, Robert E. Davis
Life of this patent
Estimating the term…
Abstract
Cobalt-porphyrin (Co-P) complexes for use as anti-obesity agents, and compositions and methods related thereto. The Co-P complexes exhibit reduced redox activity compared to cobalt mesoporphyrin (Co-MP) and cobalt protoporphyrin (Co-PP), which alleviates the deleterious effects associated with administration of Co-P associated with oxidative stress, particularly in the context of injection site toxicity.
Claims3
A cobalt-porphyrin complex having the structure:
- or a salt thereof, wherein:
- R1 and R2 are both —(CH2)2C(═O)OCH(CH3)2;
- R3 and R4 are both —CH2CH3;
- and
- L1 and L2 are both glycinate.
A method for treating obesity, comprising administering an effective amount of a composition comprising a cobalt-porphyrin complex and a pharmaceutically acceptable carrier, wherein the cobalt-porphyrin complex has the structure:
- or a salt thereof, wherein:
- R1 and R2 are both —(CH2)2C(═O)OCH(CH3)2;
- R3 and R4 are both —CH2CH3;
- and
- L1 and L2 are both glycinate.
Dependencies are inferred from the claim text.