Method for producing Grignard compounds

A process for preparing compounds of the general formula I

• which comprises reacting compounds of the general formula II
• with compounds of the formula R4MgX (III) at temperatures below 0° C., where the substituents and variables in the formulae, I, II and III have the following meanings:
• wherein Z is 0 or 1
• wherein X is halogen or R2
• wherein Xa is Br, or I
• wherein A, B, D and E
• independently of one another are CH, CR2, N, P or CR3 wherein F is O, S, NR6, CR2, or CR3 when z=0, or CH, CR2, N, P or CR3 when z=1,
• wherein two adjacent variables A, B, D, E or F together optionally form another substituted or unsubstituted aromatic saturated or partially saturated ring which has 5 to 8 atoms in the ring and which may contain one or more heteroatoms such as O, N, S, P, and not more than three of the variables, A, B, D, E or F being a heteroatom,
• wherein R1 is COOR2, CN, CONR3R3, or Halogen
• wherein R2 is substituted or unsubstituted, branched or unbranched C1-C10-alkyl, C3-C10-cycloalkyl, C1-C4-alkylaryl, C1-C4-alkylhetaryl, or R5,
• wherein R3 is hydrogen, substituted or unsubstituted, branched or unbranched —OC1-C10-alkyl, —OC3-C10-cycloalkyl, —OC1-C4-alkylaryl, —oC1-C4-alkylhetaryl, R3 or R5,
• wherein R3 is hydrogen, substituted or unsubstituted, branched or unbranched C1-C10-alkyl, C3-C10-cycloalkyl, C1-C4-alkylaryl, C1-C4-alkylhetaryl, or R5,
• wherein R4 is substituted or unsubstituted, branced or unbranched C1-C10-alkyl, C3-C10-cycloalkyl, C1-C4-alkylaryl, C1-C4-alkylhetaryl, or halogen,
• wherein R5 is a solid support,
• wherein R6 is substituted or unsubstituted, branched or unbranched C1-C10-alkyl, C3-C10-cycloalkyl, C1-C4-alkylaryl, C1-C4-alkylhetaryl, substituted or unsubstituted, branched or unbranched —(C═O)—C1-C10-alkyl, —(C═O)—C3-C10-cycloalkyl, —(C═O)—C1-C4-alkylaryl, —(C═O)—C1-C4-alkylhetaryl or —SO2—aryl
• where the process is caried out on a solid support (R5).