Zsig33-like peptides
AssigneeZymoGenetics, Inc.
InventorsStephen R. Jaspers, Paul O. Sheppard, Theresa A. Deisher, Paul D. Bishop
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Abstract
The present invention relates to peptides related to the zsig33 peptide, including agonists, antagonists, and antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and hormones, and/or secretion of enzymes and/or hormones in the pancreas are also included.
Claims13
An isolated polypeptide consisting of an amino acid sequence selected from the group consisting of:
- a) the amino acid sequence as shown in SEQ ID NO:4;
- b) the amino acid sequence as shown in SEQ ID NO:5;
- and
- c) the amino acid sequence as shown in SEQ ID NO:6.
An isolated polypeptide consisting of the amino acid sequence as shown in SEQ ID NO:
- 4, wherein the polypeptide has an addition, and wherein the addition is selected from the group consisting of:
- a) an amino-terminal extension;
- b) a carboxyl-terminal extension;
- c) a linker peptide;
- and
- d) an affinity tag.
An isolated polypeptide consisting of the amino acid sequence as shown in SEQ ID NO:
- 5, wherein the polypeptide has an addition, and wherein the addition is selected from the group consisting of:
- a) an amino-terminal extension;
- b) a carboxyl-terminal extension;
- c) a linker peptide;
- and
- d) an affinity tag.
An isolated polypeptide consisting of the amino acid sequence as shown in SEQ ID NO:
- 6, wherein the polypeptide has an addition, and wherein the addition is selected from the group consisting of:
- a) an amino-terminal extension;
- b) a carboxyl-terminal extension;
- c) a linker peptide;
- and
- d) an affinity tag.
Dependencies are inferred from the claim text.