US 6,897,220 B2 · Inhibitors of histone deacetylase

Abstract

The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

Claims4

Dependent claims

A histone deacetylase inhibitor of formula (1):

or a pharmaceutically acceptable salt thereof.

Dependencies are inferred from the claim text.

Facts

Application

10/358,556Filed 4 Feb 2003 · continuation in part

Priority

14 Sep 2001

Published

US 2004/0106599 A122 Jul 2004

Granted

24 May 2005

Term ends

Not estimatedThe source records don’t support an estimate.

Classification72 codes

C07D 401/04
Containing two hetero rings: directly linked by a ring-member-to-ring-member bond
A61K 31/4015
Having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil: having oxo groups…
A61K 31/445
Non condensed pyridines; Hydrogenated derivatives thereof: non condensed piperidines, e.g. piperocaine
A61K 31/495
Having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins: having six-membered rings with two or more nitrogen atoms as the only ring…

Family

Application60/322,402Us provisional application · filed 14 Sep 2001

Application60/391,728Us provisional application · filed 26 Jun 2002

Application10/242,304Parent of this continuation-in-part · filed 12 Sep 2002

US 2004/0142953 A1Pre-grant publication · published 22 Jul 2004

US 2004/0106599 A1Published application

US 7,595,343 B2Related patent

US 6,897,220 B2This patent

From the US filing history. Foreign family members aren’t listed.

Abstract

Facts

Application

10/358,556Filed 4 Feb 2003 · continuation in part

Priority

14 Sep 2001

Published

US 2004/0106599 A122 Jul 2004

Granted

24 May 2005

Term ends

Not estimatedThe source records don’t support an estimate.

Classification72 codes

C07D 401/04
Containing two hetero rings: directly linked by a ring-member-to-ring-member bond
A61K 31/4015
Having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil: having oxo groups…
A61K 31/445
Non condensed pyridines; Hydrogenated derivatives thereof: non condensed piperidines, e.g. piperocaine
A61K 31/495
Having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins: having six-membered rings with two or more nitrogen atoms as the only ring…

Family

Application60/322,402Us provisional application · filed 14 Sep 2001

Application60/391,728Us provisional application · filed 26 Jun 2002

Application10/242,304Parent of this continuation-in-part · filed 12 Sep 2002

US 2004/0142953 A1Pre-grant publication · published 22 Jul 2004

US 2004/0106599 A1Published application

US 7,595,343 B2Related patent

US 6,897,220 B2This patent

From the US filing history. Foreign family members aren’t listed.

Inhibitors of histone deacetylase

Life of this patent

Abstract

Claims4

Inhibitors of histone deacetylase

Life of this patent

Abstract

Claims4