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US 6,890,421 B2Granted
Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations
AssigneeLifeScan, Inc.
InventorsTimothy J. Ohara, Mahyar Z. Kermani
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Abstract
Methods and devices for determining the concentration of an analyte in a physiological sample are provided which correct for errors in the analyte concentration measurement which are due to the hematocrit of the sample.
Claims3
A method for determining the concentration of an analyte in a physiological sample, said method comprising:
- (a) introducing said physiological sample into an electrochemical cell comprising:
- (i) spaced apart working and reference electrodes;
- and
- (ii) a redox reagent system comprising an enzyme and a mediator;
- (b) applying a first electric potential having a first polarity to said reaction cell and measuring cell current as a function of time to obtain a first time-current transient;
- (c) applying a second electric potential having a second polarity to said cell, wherein said second polarity is opposite said first polarity, and measuring cell current as a function of time to obtain a second time-current transient;
- (d) deriving a preliminary analyte concentration from said first and second time-current transients;
- and
- (e) multiplying said preliminary analyte concentration less a background value by a correction factor to derive said corrected analyte concentration in said sample;
- whereby the corrected concentration of said analyte in said sample is determined.
7 more elements
Dependencies are inferred from the claim text.