Energy beam guide for an electrophoresis system
AssigneeApplera Corporation
InventorAlbert L. Carrillo
Life of this patent
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Abstract
The energy beam guide comprises a first region having a first refractive index, the first region having an energy beam receiving end and an inclined first boundary opposing the energy beam receiving end. The energy beam guide also includes a second region having a second refractive index that is less than the first refractive index. The second region shares the first boundary with the first region, and has a declined second boundary opposing the first boundary. A predetermined distance separates the first and second boundaries. Finally, the energy beam guide comprises a third region having a third refractive index. The third region shares the second boundary with the second region. Also provided are a method for making and using the energy beam guide.
Claims32
A detection cell, comprising:
- a substrate;
- a first cavity formed in said substrate, said first cavity having a first cavity sloped wall and configured to receive a first substance having a first refractive index, wherein said substrate has a second refractive index;
- a second cavity formed in said substrate, said second cavity having a second cavity sloped wall and configured to receive a second substance having a third refractive index;
- and
- a wall defined by a region of said substrate separating said first and second cavities from each other by a predetermined distance, wherein said first refractive index is larger than said second refractive index.
A method for making a detection cell, comprising:
- providing a substrate defining first and second cavities each having sloped walls and separated by a wall;
- filling said first cavity with a first substance having a first refractive index, where said substrate has a second refractive index;
- filling said second cavity with a second substance having a third refractive index;
- wherein said first refractive index is larger than said second refractive index.
A method for detecting component parts of a sample, comprising:
- directing an energy beam at a first region having a first refractive index;
- redirecting said energy beam towards a second boundary, where said redirecting occurs at an inclined first boundary separating said first region from a second region having a second refractive index;
- guiding said energy beam towards a third region that includes component parts of a sample, where said guiding occurs at a declined second boundary separating said second region from said third region;
- striking said component parts with said energy beam;
- and
- detecting energy emitted from said component parts;
- wherein said first refractive index is larger than said second refractive index.
Dependencies are inferred from the claim text.