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US 6,888,010 B2Granted
Process for the preparation of 5-formylphthalide
AssigneeInfosint SA
InventorsLeone Dall'Asta, Giovanni Cotticelli
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Abstract
There is described a process for the preparation of 5-formylphthalide by hydrogenation of a halide of 5-carboxyphthalide, dissolved in a dipolar aprotic solvent, in the presence of a catalyst. Furthermore, the use of 5-formylphthalide in the preparation of citalopram is described.
Claims10
A process for the preparation of 5-formylphthalide of formula
- which comprises submitting a halide of formula
- wherein Hal represents chlorine, bromine or iodine, dissolved in a dipolar aprotic solvent to hydrogenation,
- where the dipolar aprotic solvent is selected from the group consisting of N,N-dimethylformamide (DMF), N,N-dimeithylacetamicde (DMA), dimethylsulfoxide (DMSO) and acetonitrile, and
- where the hydrogenation is carried out in the presence of a hydrogenation catalyst selected from the group consisting of palladium on charcoal (Pd/C) and palladium on barium sulphate (Pd/BaSO2).
1 more element
Dependencies are inferred from the claim text.