Preparation of dihydrocodeine from codeine
AssigneeAcura Pharmaceuticals, Inc.
InventorIgor Likhotvorik
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Abstract
A process for the preparation of dihydrocodeine by hydrogenating codeine or a salt thereof in aqueous solution in the presence of a catalytic metal and deactivating agent that decreases impurities formation.
Claims17
A process for the production of dihydrocodeine, which comprises reacting codeine or a salt thereof in an aqueous solution with hydrogen in the presence of
- (i) at least one catalytic metal selected from group VIII of the Periodic Table of Elements;
- and
- (ii) at least one deactivating agent that decreases impurities formation.
A process for the production of dihydrocodeine, which comprises reacting codeine or a salt thereof in an aqueous solution with hydrogen in the presence of
- (i) at least one a catalytic metal selected from group VIII of the Periodic Table of Elements;
- and
- (ii) at least one inorganic base that decreases impurities formation.
A process for the production of dihydrocodeine, which comprises reacting codeine or a salt thereof in an aqueous solution with hydrogen in the presence of
- (i) at least one catalytic metal selected from the group consisting of nickel, palladium, rhodium, ruthenium, platinum;
- and
- (ii) at least one base that decreases impurities formation.
Dependencies are inferred from the claim text.