C-nitroso compounds and use thereof
AssigneeDuke University
InventorsJonathan S. Stamler, Eric J. Toone
Life of this patent
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Abstract
A C-nitroso compound having a molecular weight ranging from about 225 to about 1,000 (from about 225 to about 600 for oral administration) on a monomeric basis wherein a nitroso group is attached to a tertiary carbon, which is obtained by nitrosylation of a carbon acid having a pKa less than about 25, is useful as an NO donor. In another case, the C-nitroso compound contains the moiety —C—N(O)X— where X is S, O or NR. One embodiment is directed to COX-2 inhibitors where a tertiary carbon atom and/or an oxygen atom and/or a sulfur atom is nitrosylated.
Claims2
A compound consisting of H+ with a counterion having the structure:
- where X is S, O or NR where R is selected from the group consisting of C1-C6 alkyl which is unsubstituted or which is substituted with one or more alcohol, ether, ester or amide groups which contain from 2 to 10 carbon atoms and n ranges from 0 to 4, where the structure may be substituted with C1-C6 alkyl or C1-C6 alkyl carbonyl.
Dependencies are inferred from the claim text.