Method of preventing decrease in the activity of protein due to freezing and use of polypeptide in the production of protein activity decrease preventing agent

A method for preventing freeze-induced decrease in activity of a protien of interest comprising adding a polypeptide comprising the following amino acid sequence (I) to the protein of interest:

• Ser-Sesr-Thr-Gly-Ser-X1-Ser-X2-Thr-Asp-X3-X4-X5-X6-X7-X8-Gly Ser-X9-Thr-Ser-Gly-Gly-Ser-Ser-Thr-Tyr-Gly-Tyr-Ser-Ser-X10-X11-X12-X13-Gly-X14-Val (I) (SEQ ID NO:
• 1)
• wherein,
• X1 represents Ser or Thr,
• X2 represents Asn or Thr,
• X3 represents Aer or Ala,
• X4 represents Asn or Ser,
• X5 represents Ser or Thr,
• X6 represents Asn, Asp, or Lys,
• X7 represents Ser, Asn, or Lys,
• X8 represents Ala, Thr, or Val,
• X9 represents Ser, or Arg,
• X10 represents Asn, Ser, Asp, or Arg,
• X11 represents Ser, Asn, His, or Cys,
• X12 represents Arg or Gly,
• X13 represents Asp or Gly, and
• X14 represents Ser or Arg.