Back to results
US 6,887,977 B1Granted
Methods and materials relating to CD8-tropic HIV-1
AssigneeChildren's Hospital, Inc.
InventorKunal Saha
Life of this patent
Estimating the term…
Abstract
The present invention relates to human immunodeficiency viruses 1 (HIV-1) that infect CD8-positive cells using CD8 as a receptor, to detection methods for the viruses and to prophylactic and therapeutic methods for infection by the viruses.
Claims6
An isolated gp20 polypeptide comprising the amino acid sequence of SEQ ID NO:
- 10 or a fragment of the amino acid sequence of SEQ ID NO:
- 10 wherein the fragment binds to a CD8 protein.
An isolated HIV-1 gp120 polypeptide comprising an amino acid sequence encoded by a nucleotide sequence that hybridizes to the complement of the nucleotide sequence of SEQ ID NO:
- 9 under the following hybridization wash conditions:
- 0.015 M sodium chloride, 0.0015 M sodium citrate at 65-68° C., and
- wherein the polypeptide binds to a CD8 protein.
An isolated HIV-1 gp120 polypeptide comprising an amino acid sequence of SEQ ID NO:
- 10 having at least one conservative substitution, wherein the polypeptide binds to CD8 protein.
Dependencies are inferred from the claim text.