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US 6,887,960 B2Granted
Bioadhesive composition
AssigneeRohm and Haas Company
InventorsHsing-Yeh Parker, Allan Sachs Hoffman
Life of this patent
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Abstract
A bioadhesive composition is disclosed which includes copolymer particles containing as polymerized units, terminally unsaturated acid-containing oligomers and ethylenically unsaturated nonionic monomers. A method of preparing the bioadhesive composition and a method of using the bioadhesive composition are also disclosed.
Claims10
A process for preparing a bioadhesive composition comprising copolymer particles comprising:
- a) providing a reaction mixture comprising:
- i) from 60 weight % to 99 weight % based on weight of said copolymer particles, of at least one ethylenically unsaturated nonionic monomer and
- ii) from 40 weight % to 1 weight % based on weight of said copolymer particles, of at least one oligomer selected from the group of oligomers with formulas:
- wherein N is the residue of an ethylenically unsaturated carboxylic acid monomer and has the formula:
- wherein M is the residue of a second ethylenically unsaturated monomer and has the formula:
- wherein said N and M residues are randomly arranged in said oligomer;
- wherein m is the total number of M residues in said oligomer and is in t the range of 0 to 150;
- wherein n is the total number of N residues in said oligomer and is in the range of 2 to 300;
- wherein n is greater than or equal to m;
- wherein the sum of n and m is in the range of 2 to 300;
- wherein X is selected from the group consisting of —COOY and R;
- wherein R is selected from phenyl radicals, substituted phenyl radicals, —CONH2, —CONHR′, —CONR′R′, —CN, —COOR′, —OCOR′, —Cl, and mixtures thereof, wherein R′ is an alkyl or alkoxyalkyl radical independently selected from the group consisting of branched, unbranched, or cyclic hydrocarbon radicals having 1 to 18 carbon atoms;
- wherein Y is independently selected from the group consisting of H, NH4, alkali metals and alkaline earth metals;
- and
- wherein each Z is independently selected from the group consisting of H and CH3,
- b) polymerizing said reaction mixture;
- and
- c) forming copolymer particles and d) adding a therapeutic substance.
15 more elements
The method of using a bioadhesive composition comprising:
- a) preparing a composition comprising copolymer particles and at least one therapeutic agent, wherein said copolymer particles comprise, as polymerized units, from 60 weight % to 99 weight % based on weight of said copolymer particles, of at least one ethylenically unsaturated nonionic monomer and from 40 weight % to 1 weight % based on weight of said copolymer particles, of at least one oligomer selected from the group of oligomers with formulas:
- wherein N is the residue of an ethylenically unsaturated carboxylic acid monomer and has the formula:
- wherein M is the residue of a second ethylenically unsaturated monomer and has the formula:
- wherein said N and M residues are randomly arranged in said oligomer;
- wherein m is the total number of M residues in said oligomer and is in t the range of 0 to 150;
- wherein n is the total number of N residues in said oligomer and is in the range of 2 to 300;
- wherein n is greater than or equal to m;
- wherein the sum of n and m is in the range of 2 to 300.
5 more elements
A bioadhesive composition comprising copolymer particles comprising, as polymerized units,
- a) from 60 weight % to 99 weight % based on weight of said copolymer particles, of at least one ethylenically unsaturated nonionic monomer and
- b) from 40 weight % to 1 weight % based on weight of said copolymer particles, of at least one oligomer selected from the group of oligomers with formulas:
- wherein N is the residue of an ethylenically unsaturated carboxylic acid monomer and has the formula:
- wherein M is the residue of a second ethylenically unsaturated monomer and has the formula:
- wherein said N and M residues are randomly arranged in said oligomer;
- wherein m is the total number of M residues in said oligomer and is in the range of 0 to 150;
- wherein n is the total number of N residues in said oligomer and is in the range of 2 to 300;
- wherein n is greater than or equal to m;
- wherein the sum of n and m is in the range of 2 to 300;
- wherein X is selected from the group consisting of —COOY and R;
- wherein R is selected from phenyl radicals, substituted phenyl radicals, —CONH2, —CONHR′, —CONR′R′, —CN, —COOR′, —OCOR′, —Cl, and mixtures thereof, wherein R′ is an alkyl or alkoxyalkyl radical independently selected from the group consisting of branched, unbranched, or cyclic hydrocarbon radicals having 1 to 18 carbon atoms;
- wherein Y is independently selected from the group consisting of H, NH4, alkali metals and alkaline earth metals;
- and
- wherein each Z is independently selected from the group consisting of H and CH3,
- and a therapeutic substance.
12 more elements
The bioadhesive composition of claim 11 wherein m=0 and X=—COOY.
Dependencies are inferred from the claim text.