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US 6,887,904 B2Granted
Substituted arylcycloalkanes, compositions containing them and use thereof
AssigneeAventis Pharma S. A.
InventorsPatrick Mailliet, Marc Capet, Gilles Tiraboschi, Thomas Caulfield
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Abstract
Substituted arylcycloalkanes, compositions containing them and use thereof. The present invention relates especially to substituted arylcycloalkanes with therapeutic activity, which may be used such as in oncology.
Claims13
A product corresponding to formula (I) below:
- in which:
- A represents a saturated or partially unsaturated, optionally substituted cyclic hydrocarbon containing from 3 to 14 carbon atoms;
- X is selected from O and N—O—(R2),
- each radical R or (R2) is independently selected from H, C1-C7 alkyl, cyclo(C3-C9)alkyl(C1-C7)alkylaryl(C1-C7)alkyl-, substituted C1-C7 alkyl, substituted cyclo(C3-C9)alkyl(C1-C7)alkyl-, and substituted aryl(C1-C7)alkyl-, or R is a halogen and (R2) is as defined above,
- Ar1 represents a first phenyl nucleus, substituted with 1 to 4 radicals O(R3), in which R3 is independently selected from H and C1-C3 alkyl, and in which an R3 may be simultaneously linked to two adjacent oxygen atoms borne by the, first phenyl nucleus, and
- Ar2 is selected from 3-hydroxy-4-methoxyphenyl;
- 4-hydroxy-3-methoxyphenyl;
- 3-hydroxy-4-aminophenyl;
- 4-hydroxy-3-aminophenyl;
- 3-hydroxy-4-(N,N-dimethylamino)phenyl;
- and 4-hydroxy-3-(N,N-dimethylamino)phenyl.
8 more elements
Dependencies are inferred from the claim text.