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US 6,887,903 B1Granted
N-(2-aryl-propionyl)-sulfonamides and pharmaceutical preparations containing them
AssigneeDompe S.p.A.
InventorsRiccardo Bertini, Cinzia Bizzarri, Vilma Sabbatini, Gianfranco Caselli, Marcello Allegretti, Maria Candida Cesta, Carmelo Gandolfi, Marco Mantovanini, Francesco Colotta, Stefano Porzio
Life of this patent
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Abstract
The compounds of formula 1 wherein R and R2 are as defined in the disclosure, are useful in the prevention and treatment of tissue damage due to exacerbated recruitment of polymorphonuclear neutrophils (PMN leukocytes) at the inflammatory sites.
Claims12
A compound of formula 1
- in which
- R is an aryl group,
- R is a straight or branched C1-C16-alkyl, trifluoromethyl, cyclohexyl, o-tolyl, 3-pyridyl, 2-pyridyl-ethyl, p-cyanophenylmethyl, p-aminophenylmethyl, 3-cyano-1-propyl, 4-aminobutyl group, an alkoxyethylene CH3—(CH2)ni—(OCH2CH2)mi— group in which ni is zero or 1 and mi is an integer 1 to 3, or a P1P2N—CH2—CH2— group in which P1 and P2 are independently H, C1-C3-alkyl, benzyloxy-carbonyl, α-, β- or γ-pyridocarbonyl, carboxycarbonyl or carbalkoxycarbonyl, or P1 and P2, when joined to the N atom which they are linked to, form a phthalimido, piperidino, morpholino residue;
- R′ is H or straight or branched C1-C3-alkyl and salts thereof with strong and medium bases.
1 more element
Dependencies are inferred from the claim text.