7-[(7-Alkoxy)-chrom-3-en-6-yl]-heptatrienoic acid and 7-[(3-alkoxy)-5,6-dihydronaphthalen-2-yl]-heptatrienoic acid derivatives having serum glucose reducing activity

A compound of the formula

• wherein
• R is alkyl of 1 to 8 carbons;
• R1 is alkyl of 1 to 8 carbons;
• R2 is alkyl of 1 to 8 carbons;
• R4 is H, alkyl of 1 to 6 carbons, CH2OR5 or CH2OCOR5 where R5 is alkyl of 1 to 3 carbons, and
• X is H or halogen, or a pharmaceutically acceptable salt of said compound.

A compound of the formula

• wherein
• R is alkyl of 1 to 8 carbons;
• R1 is phenyl, or alkyl of 1 to 8 carbons;
• R2 is alkyl of 1 to 8 carbons, and R4 is H, alkyl of 1 to 6 carbons, CH2OR5 or CH2OCOR5 where R5 is alkyl of 1 to 3 carbons, or a pharmaceutically acceptable salt of said compound.

A compound of the formula

• wherein
• R is alkyl of 1 to 8 carbons;
• R1 is alkyl of 1 to 8 carbons, and
• R4 is H, alkyl of 1 to 6 carbons, CH2OR5 or CH2OCOR5 where R5 is alkyl of 1 to 3 carbons, or a pharmaceutically acceptable salt of said compound.

A compound of the formula

• wherein
• R is alkyl of 1 to 8 carbons;
• R1 is alkyl of 1 to 8 carbons, and
• R4 is H, alkyl of 1 to 6 carbons, CH2OR5 or CH2OCOR5 where R5 is alkyl of 1 to 3 carbons, or a pharmaceutically acceptable salt of said compound.

A compound of the formula

• wherein
• R is H, or alkyl of 1 to 8 carbons;
• R1 is alkyl of 1 to 8 carbons;
• R2 is alkyl of 1 to 8 carbons, and
• R4 is H, alkyl of 1 to 6 carbons, CH2OR5 or CH2OCOR5 where R5 is alkyl of 1 to 3 carbons, or a pharmaceutically acceptable salt of said compound.

A compound of the formula

• wherein
• R represents alkyl of 1 to 8 carbons;
• R1 is alkyl of 1 to 8 carbons;
• R2 is alkyl of 1 to 8 carbons;
• X is halogen, and
• R4 is H, alkyl of 1 to 6 carbons, CH2OR5 or CH2OCOR5 where R5 is alkyl of 1 to 3 carbons, or a pharmaceutically acceptable salt of said compound.

A process for administering to a diabetic mammal to reduce the serum glucose level of said mammal a compound of the formula

• wherein
• A is independently an alkyl group of 1 to 6 carbons, halogen, or alkoxy of 1 to 6 carbons;
• m is an integer having the values of 0 to 3;
• W is H, alkyl of 1 to 8 carbons or phenyl;
• E is independently an alkyl group of 1 to 6 carbons, halogen, or alkoxy of 1 to 6 carbons;
• n is an integer having the values of 0 to 2;
• Z is an alkyl group of 1 to 8 carbons;
• G is H or an alkyl group of 1 to 8 carbons;
• J is independently H, halogen, or alkyl of 1 to 6 carbons;
• Y is O, or [C(R3)-2]0 where R3 independently is H or alkyl of 1 to 6 carbons and o is an integer having the value of zero (0) or one (1), and
• R4 is H, alkyl of 1 to 6 carbons, CH2OR5 or CH2OCOR5 where R5 is alkyl of 1 to 3 carbons, or a pharmaceutically acceptable salt of said compound.