Tricyclic derivatives of indole with antiangiogenic activity

A compound having the formula (I):

• wherein:
• X=CH
• X1=N
• R and R1, which are the same or different, are selected from the group consisting of —H, OH, OR5 in which R5 may be C1-C4 alkyl or benzyl, when two groups OR5 are vicinal R5 is methylene;
• or R and R1 may be independently nitro;
• amino optionally mono- or di-substituted with C1-C4 alkyl;
• carboxy;
• or alkoxy (C1-C4) carbonyl;
• R and R1 taken together form an aliphatic or aromatic cyclic group having 5 or 6 atoms;
• R2 is selected from the group consisting of —H, phenyl, benzyl, linear or branched C1-C6 alkyl;
• n=is an integer ranging from 0 and 4;
• R3, which is the same as or different from R4, is —H, —OH, —OR6, wherein R6 is linear or branched C1-C4 alkyl, or when R3=R4=OR6 vicinal, R6 is isopropylidene
• R7=C1-C4 linear or branched alkyl optionally substituted with one or two groups OH, OR6, in case of 2 groups OR6 vicinal, R6 is isopropylidene;
• or R7 is formyl (CHO), oxime (CH═NOH), their isomers and their mixtures.