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US 6,887,891 B2Granted
Derivatives of lipoic acid, their preparation, their use as medicaments and the pharmaceutical compositions containing them
AssigneeSociete de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
InventorsJeremiah Harnett, Michel Auguet, Pierre-Etienne Chabrier de Lassauhyere
Life of this patent
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Abstract
Compounds of formula wherein the substituents are as defined in the specification which compounds are useful for inhibiting the activity of NO-synthase enzymes.
Claims12
A compound of a formula selected from the group consisting of
- wherein
- A is selected from the group consisting of —(CH2)m—NR3CO(CH2)n—, —(CH2m)—CONR—(CH2)n—, —(CH2)m—NR3—(CH2)n, —(CH2)m—CONR3—(CH2)p—NR4—(CH2)n—, —(CH2)m—NR3—CO—NR4—(CH2)n— and —(CH2)m—,
- m and n are individually integers from 0 to 6,
- p being an integer from 2 to 6,
- and R3 and R4 are individually hydrogen or alkyl of 1 to 6 carbon atoms;
- X is
- wherein the T group, which is attached to the Y group, is —(CH2)i-, i is 0 and R5 is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and —(CH2)m-Q, Q is selected from the group consisting of halogen, hydroxy, cyano, amino, alkoxy, alkylamino, dialkylamino and a heterocycle with 5 to 6 ring members with the heterocyclic members being selected from the group consisting of —O—, —N(R6)— and —S—, R6 is hydrogen or alkyl of 1 to 6 carbon atoms or the bond to the phenyl ring of X;
- and Y is
- and R7 is hydrogen or alkyl of 1 to 6 carbon atoms and
- a pharmaceutically acceptable salt thereof.
7 more elements
Dependencies are inferred from the claim text.