Therapeutic compositions comprising excess enantiomer
AssigneePfizer Inc.
InventorsSuresh Babubhai Chahwala, Michael George Dodd, Michael John Humphrey
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Abstract
The present invention is concerned with pharmaceutical compositions comprising a mixture of amlodipine enantiomers, which compositions have both anti-hypertensive and additional cardiovascular properties derived respectively from their calcium channel-blocking activity and their ability to release vascular nitric oxide (NO).
Claims19
A pharmaceutical composition comprising an NO-releasing amount of the R(+) enantiomer of amlodipine or of a pharmaceutically acceptable salt thereof, an anti-hypertensive amount of the S(−) enantiomer of amlodipine or of a pharmaceutically acceptable salt thereof and a suitable excipient, diluent, or carrier, wherein the enantiomers are present in a ratio by weight (based on free base) of R(+) enantiomer:
- S(−) enantiomer of 2:1 to 8:1.
Dependencies are inferred from the claim text.