Aryl fused azapolycyclic compounds

A compound of the formula

• R1 is hydrogen, (C1-C6)alkyl, unconjugated (C3-C6)alkenyl, XC(═O)R13 , benzyl or —CH2CH2—O—(C1-C4)alkyl;
• R2 and R3 are selected, independently, from hydrogen, (C2-C6)alkenyl, (C2-C6)alkynyl, hydroxy, nitro, amino, halo, cyano, —SOq(C1-C6)alkyl wherein q is zero, one or two, (C1-C6)alkylamino-, [(C1-C6)alkyl]2amino-, —CO2R4, —CONR5R6, —SO2NR7R8, —C(═O)R13, —XC(═O)R13, aryl-(C0-C3)alkyl- or aryl-(C0-C3)alkyl-O—, wherein said aryl is selected from phenyl and naphthyl, heteroaryl-(C0-C3)alkyl- or heteroaryl-(C0-C3)alkyl-O—, wherein said heteroaryl is selected from five to seven membered aromatic rings containing from one to four heteroatoms selected from oxygen, nitrogen and sulfur, and X2(C0-C6)alkoxy-(C0-C6)alkyl-, wherein X2 is absent or X2 is (C1-C6)alkylamino- or [(C1-C6)alkyl]2amino-, and wherein the (C0-C6)alkoxy-(C0-C6)alkyl- moiety of said X2(C0-C6)alkoxy-(C0-C6)alkyl- contains at least one carbon atom, and wherein from one to three of the carbon atoms of said (C0-C6)alkoxy-(C0-C6)alkyl- moiety may optionally be replaced by an oxygen, nitrogen or sulfur atom, with the proviso that any two such heteroatoms must be separated by at least two carbon atoms, and wherein any of the alkyl moieties of said (C0-C6)alkoxy-(C0-C6)alkyl- may be optionally substituted with from two to seven fluorine atoms, and wherein one of the carbon atoms of each of the alkyl moieties of said aryl-(C0-C3)alkyl- and said heteroaryl-(C0-C3)alkyl- may optionally be-replaced by an oxygen, nitrogen or sulfur atom, and wherein each of the foregoing aryl and heteroaryl groups may optionally be substituted with one or more substituents independently selected from (C1-C6)alkyl optionally substituted with from one to seven fluorine atoms, (C1-C6)alkoxy optionally substituted with from two to seven fluorine atoms, halo, (C2-C6)alkenyl, (C2-C6)alkynyl, hydroxy, nitro, cyano, amino, (C1-C6)alkylamino-, [(C1-C6) alkyl]2amino-, —CO2R4, —CONR5R6, —SO2NR7R8, —C(═O)R13 and —XC(═O)R13;
• wherein each R4, R5, R6, R7, R8 and R13 is selected, independently, from hydrogen and (C1-C6) alkyl, or R5 and R6, or R7 and R8 together with the nitrogen to which they are attached, form a pyrrolidine, piperidine, morpholine, azetidine, piperazine, N-(C1-C6)alkylpiperizine or thiomorpholine ring, or a thiomorpholine ring wherein the ring sulfur is replaced with a sulfoxide or sulfone;
• and
• each X is, independently, (C1-C6)alkylene;
• with the proviso that:
• (a) at least one of R1, R2 and R3 must be other than hydrogen, [and ](b) when R2 and R3 are both hydrogen, R1 cannot be hydrogen, (C1-C6)alkyl, or unconjugated (C3-C6)alkenyl;
• (c) both R2 and R3 cannot both simultaneously be nitro;
• and (d) when both R2 and R3 are amino and meta to a fused ring carbon atom then R1 cannot be hydrogen, methyl or benzyl;
• and pharmaceutically acceptable salts thereof.