Pharmaceutical compositions comprising chelidonine or derivatives thereof
AssigneesJae-Soon Eun, Yong-Geun Kwak, Dae-Keun Kim, Soo-Wan Chae, Young-Hoon Jung, Ok-Pyo Zee
InventorsJae-Soon Eun, Yong-Geun Kwak, Dae-Keun Kim, Soo-Wan Chae
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Abstract
The present invention relation to a pharmaceutical composition comprising chelidonine or derivatives thereof, with pharmaceutically acceptable carriers. The compositions according to the present invention can selectively block hKv1.5 channels expressed preferentially in human atrial myocytes, and thus are useful as K+ channel blockers and antiarrhythmic drugs.
Claims16
A method for preventing or treating arrhythmias wherein the method comprises administering to a mammal a composition comprising a therapeutically effective amount of chelidonine or derivatives thereof represented by the following formula 1, with pharmaceutically acceptable carriers:
- wherein,
- R1 is selected from the group consisting of hydrogen, hydroxy, a lower alkoxy having 1 to 5 carbon atoms, benzyloxy, a lower alkylcarbonyloxy having 1 to 5 carbon atoms, benzoyloxy, a lower alkylsulfonyloxy having 1 to 5 carbon atoms, arylsulfonyloxy, diphenylphosphonyloxy, and —OCONH2;
- R2 is hydrogen or methyl;
- and
- R3, R4 and R5 are each, independently, hydrogen;
- or
- R1 forms a double bond with R2 or R4;
- or
- R2 forms a double bond with R3;
- or
- R5 forms a double bond with the adjacent N atom.
A method for preventing or treating K+ channel-mediated myocardial diseases wherein the method comprises administering to a mammal a composition comprising a therapeutically effective amount of chelidonine or derivatives thereof represented by the following formula 1, with pharmaceutically acceptable carriers:
- wherein,
- R1 is selected from the group consisting of hydrogen, hydroxy, a lower alkoxy having 1 to 5 carbon atoms, benzyloxy, a lower alkylcarbonyloxy having 1 to 5 carbon atoms, benzoyloxy, a lower alkylsulfonyloxy having 1 to 5 carbon atoms, arylsulfonyloxy, diphenylphosphonyloxy, and —OCONH2;
- R2 is hydrogen or methyl;
- and
- R3, R4 and R5 are each, independently, hydrogen;
- or
- R1 forms a double bond with R2 or R4;
- or
- R2 forms a double bond with R3;
- or
- R5 forms a double bond with the adjacent N atom.
Dependencies are inferred from the claim text.