Pharmaceutical combination of antiviral agents
AssigneeShire BioChem Inc.
InventorsRobert F. Rando, Zhengxian Gu
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Abstract
In accordance with the present invention there is provided a pharmaceutical combination useful for the treatment of viral infections comprising a at least one antiviral active compound of formula (1): and at least one further therapeutic agent chosen from nucleoside analogues; NNRTIs; and protease inhibitors.
Claims48
A method of treating a patient infected with an HIV virus resistant to zidovudine, lamivudine and/or nevirapine, comprising administering to said patient an effective amount of (−)-β-D-2,6-diaminopurine and/or (−)-β-D-1,3-dioxolane and/or (−)-β-D-1,3-dioxolane guanine.
A pharmaceutical combination comprising (−)-β-D-2,6-diaminopurine-1,3-dioxolane or (−)-β-D-1,3-dioxolane guanine and zidovudine in a molar ratio of 10:1 to 80:1.
A pharmaceutical combination comprising (−)-β-D-2,6-diaminopurine1,3-dioxolane or (−)-β-D-1,3-dioxolane guanine and lamivudine in a molar ratio of 1:1.6 to 5:1.
A pharmaceutical combination comprising (−)-β-D-2,6-diaminopurine-1,3-dioxolane or (−)-β-D-1,3-dioxolane guanine and nevirapine in a molar ratio of 1.25:1 to 10:1.
Dependencies are inferred from the claim text.