KMST isoeugenol derivatives and pharmaceutical activity

A method of manufacturing a compound having the formula I, said method comprising the steps of:

• preparing 4-oxy-methyloxirane-3-methoxy-1-propylenyl benzene or its derivative;
• mixing phenyl piperazine dissolved in methanol with said 4-oxy-methyloxirane-3-methoxy-1-propylenyl benzene or said its derivative to reflux at 100° C. for approximately 2 to approximately 6 hours;
• removing the methanol from the mixture;
• passing the mixture through a silica gel column chromatography after the removing step;
• eluting the passed mixture with n-hexane and ethyl acetate;
• drying the eluted mixture;
• and
• crystallizing the dried mixture with methanol to obtain the compound having the formula I:
• where R1 is selected from the group consisting of an alkyl group and an alkenyl group;
• X represents
• R2 is selected from the group consisting of a halogen group, —NH2, —NO2 and a hydrogen group;
• R3 is selected from the group consisting of a hydrogen group and a hydroxyl group.

A pharmaceutical composition, comprising a compound having the formula I:

• where R1 is selected from the group consisting of an alkyl group and an alkenyl group;
• X represents
• R2 is selected from the group consisting of a halogen group, —NH2, —NO2 and a hydrogen group;
• R3 is selected from the group consisting of a hydrogen group and a hydroxyl group.