Triazine derivatives and their application as antitelomerase agents

A compound which binds a G-quadruplex structure of DNA or RNA, wherein the compound corresponds to the following formula:

• nitrogen-containing aromatic ring—NR3—distribution agent—NR′3—aromatic ring
• in which:
• the nitrogen-containing aromatic ring represents:
• a quinolinyl or isoquinolinyl radical optionally substituted with at least one radical chosen from among:
• N(Ra)(Rb), wherein Ra and Rb are identical or different and represent hydrogen or C1-C4 alkyl radical, and
• a short-chain C1-C4 alkoxy or alkyl group,
• a quinolinyl or isoquinolinyl radical possessing a nitrogen atom in quaternary form, or
• a pyridinyl radical;
• or wherein the nitrogen-containing ring is replaced by a benzimidinyl radical;
• the aromatic ring represents:
• a quinolinyl radical optionally substituted with at least one radical chosen from among:
• N(Ra)(Rb), wherein Ra and Rb are identical or different and represent hydrogen or C1-C4 alkyl radical, and a short-chain C1-C4 alkoxy or alkyl group,
• a quinolinyl radical possessing a nitrogen atom in quaternary form,
• a benzamidinyl radical,
• a pyridinyl radical,
• a phenyl ring optionally substituted with a halogen chosen from iodine, bromine or fluorine, C1-C4 alkoxy group, cyano group, carbonylamino group optionally substituted with one or more C1-C4 alkyl groups, guanyl group, C1-C4 alkylthio group, amino group, C1-C4 alkylamino group, C1-C4 dialkylamino group for each alkyl, C1-C4 dialkylamino group for each alkyl in which the alkyl portions together form a C3-C8 ring, nitro group, C1-C4 alkyleneamino group, or C2-C4 alkenyleneamino group, or
• a mono- or bi- or tricyclic heterocyclic ring comprising 0 to 2 heteroatoms per ring wherein at least one heteroatom is present in at least one ring that is optionally substituted with one or more C1-C4 alkyl groups, C1-C4 alkylene groups, or C2-C4 alkenylene groups;
• R3 and R′3 are identical or different and represent, independently of one another, hydrogen or C1-C4 alkyl radical;
• the distribution agent represents:
• a triazine group,
• wherein the triazine group is a [1,3,5]triazine optionally substituted with:
• an aromatic ring as defined above, or
• a radical XR1(R2), where X represents a nitrogen to form NR1R2, a linear or branched C1-C6 alkyl radical to form alkR1R2, an oxygen to form OR1, or a sulfur to form SR1,
• wherein R1 and R2, which are identical or different, are chosen from among hydrogen;
• a C1-C8 alkyl radical optionally substituted with one or more radicals which are identical or different;
• an aromatic ring as defined above;
• a quinuclidine radical;
• a pyrrolidinyl radical which is optionally substituted with an alkyl or phenylalkyl radical where alkyl is C1-C4 alkyl;
• a piperazinyl radical which is optionally substituted with an alkyl, cycloalkyl or phenylalkyl radical;
• a morpholinyl radical;
• a pyridyl radical or a piperidyl radical which are optionally substituted with one or more alkyl or phenylalkyl radicals where alkyl is C1-C4 alkyl;
• an indazolyl radical;
• a naphthyl radical;
• a benzotriazole radical;
• a pyrimidinyl radical optionally substituted with one or more C1-C4 alkyls;
• and an acenaphthene radical;
• or
• a radical where X represents N or alkyl, R1 and R2 are as defined above, and R1, R2 and X form a saturated or unsaturated 3- to 6-membered monocyclic or 8- to 10-membered bicyclic radical optionally containing one or two identical or different heteroatoms chosen from N, O or S;
• with the provisos that if X represents a nitrogen and R1 and R2 are identical, then R1 and R2 do not both represent hydrogen or unsubstituted C1-C4 alkyl, and
• if X represents a nitrogen and R1 and R2 are different, then one does not represent hydrogen and the other an unsubstituted C1-C4 alkyl;
• or any salts, isomeric forms, racemates, enantiomers and diastereoisomers thereof.