Hydrazide and alkoxyamide angiogenesis inhibitors

A compound of formula (I),

• or a therapeutically acceptable salt or prodrug thereof, wherein
• R1 is selected from the group consisting of alkyl, aryl, arylalkyl, cycloalkyl, (cycloalkyl)alkyl, (heterocycle)alkyl, and R5S-(alkylene)-;
• wherein each group is drawn with its right-hand end being the end that is attached to the parent molecular moiety;
• R3 is selected from the group consisting of hydrogen, alkyl, and arylalkyl;
• R4 is selected from the group consisting of —NR6R7, and —OR8;
• wherein each group is drawn with its left-hand end being the end that is attached to the parent molecular moiety;
• R5 is selected from the group consisting of alkyl, aryl, arylalkyl, cycloalkyl, and (cycloalkyl)alkyl;
• R6 and R7 are independently selected from the group consisting of hydrogen, alkanoyl, alkenyl, alkenyloxyalkyl, alkoxyalkyl, alkoxycarbonylalkyl, alkyl, alkylsulfanylalkyl, aryl, arylalkanoyl, arylalkoxyalkyl, arylalkoxycarbonyl, arylalkyl, aryloxyalkyl, (aryl)oyl, arylsulfonyl, carboxyalkyl, cycloalkyl, (cycloalkyl)alkyl, (cycloalkyl)alkanoyl, (cycloalkyl)oyl, haloalkanoyl, haloalkyl, heterocycle, (heterocycle)alkanoyl, (heterocycle)oyl, hydroxyalkyl, a nitrogen protecting group, and —C(O)NR9R10;
• or
• R6 and R7 together are arylalkylidene;
• or
• R6 and R7, together with the nitrogen atom to which they are attached, form a heterocycle;
• R8 is selected from the group consisting of hydrogen, alkanoylalkyl, alkenyl, alkoxycarbonylalkyl, alkyl, amidoalkyl, aryl, arylalkyl, arylalkoxycarbonylalkyl, (aryl)oylalkyl, carboxyalkyl, and (cycloalkyl)alkyl;
• and
• R9 and R10 are independently selected from the group consisting of hydrogen, alkyl and aryl.