(20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses
AssigneeWisconsin Alumni Research Foundation
InventorsHector F. DeLuca, Lori A. Plum, Margaret Clagett-Dame
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Abstract
This invention discloses (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat immune disorders in humans as well as renal osteodystrophy.
Claims6
A method of treating psoriasis comprising administering to a patient with psoriasis an effective amount of (20S)-1α-hydroxy-2-methylene -19-nor-bishomopregnacalciferol having the formula:
Dependencies are inferred from the claim text.