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US 6,887,847 B2Granted
Virus derived antimicrobial peptides
AssigneeUniversity of Pittsburgh
InventorsRonald C. Montelaro, Timothy A. Mietzner
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AssigneeUniversity of Pittsburgh
InventorsRonald C. Montelaro, Timothy A. Mietzner
Estimating the term…
The invention is directed to peptides having antimicrobial activity (antimicrobial peptides). The antimicrobial peptides of the present invention are analogs of the Lentivirus Lytic Peptide 1 (LLP1) amino acid sequence. The invention is further directed to peptides referred to as the Lytic Base Unit (LBU) peptides derived from the LLP1 analogs, also having antimicrobial activity. In addition, the present invention is also directed to methods of using the peptides in a variety of contexts, including the treatment or prevention of infectious diseases. The antimicrobial LLP1 analog peptides and the LBU peptides (collectively eLLPs) may be highly active under high salt conditions and in biologic fluids. In addition, the eLLPs are effective when presented either in soluble form, or when attached to a solid surface. Furthermore, the peptides of the present invention are selectively active against a wide variety of bacterial pathogens and exhibit minimal toxicity to eukaryotic cells in vitro and in vivo.
An isolated and purified having an amino acid sequence selected from the group consisting of:
An isolated and purified lentiviral lytic peptide-1 peptide analog-comprising an amino acid sequence selected from the group consisting of:
A solid phase substrate comprising at least one peptide selected from the group consisting of:
An isolated and purified peptide-cargo complex comprising a cargo and a peptide selected from the group consisting of:
Dependencies are inferred from the claim text.