Polypeptoid pulmonary surfactants
AssigneesNorthwestern University, Chiron Corporation
InventorsAnnelise E. Barron, Ronald N. Zuckermann, Cindy W. Wu
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Abstract
The present invention provides spreading agents based on sequence-specific oligomers comprising a peptoid, a peptide-peptoid chimera, a retropeptoid or a retro(peptoid-peptide) chimera, and methods for using the same, including for the treatment of respiratory distress of the lungs. The spreading agents are sequence-specific oligomers, including retrosequence-specific oligomers, based on a peptide backbone, that are designed as analogs of surfactant protein-B or surfactant protein-C.
Claims4
A pulmonary surfactant composition, comprising:
- a non-natural heteropolymeric spreading agent having the one-letter code structure
- HN-X1X2(SEQ ID NO:
- 1)(NX3)n-CONH2
- wherein X1 and X2 are selected from the group consisting of an F residue and a C-palmitoyl residue, wherein NX3 is an N-substituted peptoid monomer with X3 selected from the group consisting of ssb and spe substituents, and wherein n is an integer from about 13-20;
- and
- a lipid admixture combined with said spreading agent.
A pulmonary surfactant composition, comprising:
- a non-natural heteropolymeric spreading agent having the three-letter code structure
- HN-X1X2ProNvalNpmNleuNlysNarg(NX3)n-CONH2
- wherein X1 and X2 are selected from the group consisting of Npm, Noc and Nhd substituted glycine residues, wherein NX3 is an N-substituted peptoid monomer with X3 selected from the group consisting of spe and ssb substituents, and wherein n is an integer from about 13-20;
- and
- a lipid admixture combined with said spreading agent.
Dependencies are inferred from the claim text.