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US 6,887,844 B1Granted
NCAM binding compounds
OwnerLars Christian Ronn, Arne Holm +8inventors
InventorsLars Christian Ronn, Arne Holm, Marianne Olsen, Soren Ostergaard, Peter H. Jensen, Flemming M. Poulsen, Vladislav Soroka, Igor Ralets, Vladimir Berezin, Elisabeth Bock
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Abstract
The invention provides novel compounds which are capable to stimulate the proliferation or/and the outgrowth from cells presenting the neural cell adhesion molecule (NCAM). Additionally, the invention relates to pharmaceutical compositions, medicaments and methods for treatment of normal, degenerated and damaged NCAM presenting cells.
Claims21
A compound which is (1) a peptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 1-4, 9, 12, 14, 15, 17, and 19-22, or (2) a compound consisting of four peptides covalently linked to a backbone consisting of three lysines, said peptides each consisting of the same amino acid sequence, said sequence being selected from the group consisting of SEQ ID NOs:
- 1-4, 9, 12, 14, 15, 17, and 19-22, and wherein said compound is capable of binding to neural cell adhesion molecule (NCAM) or its isolated Ig1 or Ig2 domain.
Dependencies are inferred from the claim text.