Process for the enzymatic preparation of enantiopure 1, 3-dioxolan-4-one and 1,3-oxathiolan-5-one derivatives
AssigneeConsortium fur Elektrochemische Industrie GmbH
InventorsAlfred Popp, Jürgen Stohrer, Hermann Petersen, Andrea Gilch, Jodoca Rockinger-Mechlem
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Abstract
A process is provided for preparing an enantiopure 1,3-dioxolan-4-one or 1,3-oxathiolan-5-one derivative, which includes bringing a mixture containing enantiomeric 1,3-dioxolan-4-one or 1,3-oxathiolan-5-one derivatives and an enzyme with hydrolytic activity into contact in the presence of a nucleophile. Cleaving a dioxolanone/oxathiolanone ring of one enantiomer occurs by the enzyme with hydrolytic activity and, after the cleavage of one enantiomer has taken place, the uncleaved enantiomer of the 1,3-dioxolan-4-one or 1,3-oxathiolan-5-one derivative is isolated.
Claims14
A process for preparing an enantiopure substituted 1,3-dioxolan-4-one or an enantiopure substituted 1,3-oxathiolan-5-one which comprises
- bringing a mixture containing a substance selected from the group consisting of a recemic 1,3-dioxolan-4-one and a racemic 1,3-oxathiolan-5-one and an enzyme with hydrolytic activity into contact with an effective amount of a nucleophile to effect the biotransformation;
- cleaving the dioxolane or oxathiolane ring of one enantiomer selected from the group consisting of the 1,3-dioxolan-4-one ring and the 1,3-oxathiolan-5-one ring by the enzyme with hydrolytic activity;
- and
- after the cleaving of one enantiomer has taken place, isolating the uncleaved enantiomer selected from the group consisting of the 1,3-dioxolan-4-one and 1,3-oxathiolane-5-one.
Dependencies are inferred from the claim text.