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US 6,887,687 B2Granted
Nucleic acids encoding human ataxin-1-like polypeptide IMX97018
AssigneeImmunex Corporation
InventorDirk M. Anderson
Life of this patent
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Abstract
This invention relates to IMX97018, a new members of the human ataxin-1-like polypeptide family, methods of making such polypeptides, and to methods of using them to diagnose and treat neurological conditions and to identify compounds that alter IMX97018 polypeptide activities.
Claims11
An isolated nucleic acid consisting essentially of a nucleotide sequence encoding a polypeptide comprising an amino acid sequence selected from the group consisting of:
- (a) the amino acid sequence of SEQ ID NO:2;
- (b) an amino acid sequence selected from the group consisting of:
- amino acids 542 through 579 of SEQ ID NO:2, and amino acids 464 through 583 of SEQ ID NO:2;
- (c) an amino acid sequence selected from the group consisting of:
- amino acids 465 through 499 of SEQ ID NO:2, and amino acids 431 through 499 of SEQ ID NO:2;
- (d) an amino acid sequence selected from the group consisting of:
- amino acids 465 through 590 of SEQ ID NO:2, and amino acids 444 through 640 of SEQ ID NO:2;
- (e) a fragment of the amino acid sequences of any of (a)-(d) having IMX97018 polypeptide self-association or RNA-binding activity;
- (f) a fragment of the amino acid sequences of any of (a)-(d) comprising AXH domain amino acid sequences;
- and
- (g) an amino acid sequence having IMX97018 polypeptide self-association or RNA-binding activity, and sharing amino acid identity with the amino acid sequences of any of (b)-(f), wherein the percent amino acid identity is selected from the group consisting of:
- at least 80%, at least 85%, at least 90%, at least 95%, at least 97.5%, at least 99%, and at least 99.5%.
9 more elements
An isolated nucleic acid comprising a nucleotide sequence consisting of:
- SEQ ID NO:1.
Dependencies are inferred from the claim text.