Cloning and expression of Haemophilus somnus transferrin-binding proteins
AssigneeUniversity of Saskatchewan
InventorsAndrew A. Potter, Clement Rioux, Anthony B. Schryvers
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Abstract
Cloning and expression of genes encoding H. somnus transferrin-binding proteins are described. The transferrin-binding proteins can be used in vaccine compositions for the prevention and treatment of H. somnus infections, as well as in diagnostic methods for determining the presence of H. somnus infections.
Claims20
An isolated nucleic acid molecule comprising a coding sequence for an immunogenic H. somnus transferrin-binding protein selected from the group consisting of (a) an immunogenic H. somnus transferrin-binding protein having at least 90% sequence identity to the contiguous sequence of amino acids shown at amino acid positions 1-971, inclusive, of FIG. 3 (SEQ ID NO:2);
- (b) an immunogenic H. somnus transferrin-binding protein having at least 90% sequence identity to the contiguous sequence of amino acids shown at amino acid positions 29-971, inclusive, of FIG. 3 (SEQ ID NO:2), (c) an immunogenic H. somnus transferrin-binding protein having at least 90% sequence identity to the contiguous sequence of amino acids shown at amino acid positions 1-662, inclusive, of FIG. 4 (SEQ ID NO:3), and (d) an immunogenic H. somnus transferrin-binding protein having at least 90% sequence identity to the contiguous sequence of amino acids shown at amino acid positions 20-662, inclusive, of FIG. 4 (SEQ ID NO:3).
Dependencies are inferred from the claim text.