MyD88 adapter-like proteins
AssigneeImmunex Corporation
InventorsJohn E. Sims, Timothy A. Bird, Luke A. J. O'Neill
Life of this patent
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Abstract
There are disclosed MAL-1 polypeptides and active fragments of MAL-1, including fragments that associate with IRAK2. Further disclosed are DNAs encoding the polypeptides and fragments as well as methods of using the DNAs and polypeptides.
Claims9
A polynucleotide consisting of a nucleic acid that encodes a fragment of the polypeptide consisting of SEQ ID NO:2, wherein the fragment activates NFκB.
A polynucleotide consisting of a nucleic acid encoding a polypeptide consisting of polypeptides selected from the group consisting of:
- a) amino acids 68-236 of SEQ ID NO:2;
- b) amino acids 86-236 of SEQ ID NO:2;
- c) amino acids 86-217 of SEQ ID NO:2;
- and,
- d) amino acids 68-217 of SEQ ID NO:2.
- e) amino acids x-236 of SEQ ID NO:2 where x is any of amino acids 68-86 of SEQ IDNO:2;
- f) amino acid x1-217 of SEQ ID NO:2, where x1 is any of amino acids 68-86 of SEQ ID NO:2.
A polynucleotide that encodes the polypeptide of SEQ ID NO:2 with the proviso that the Pro at amino acid 125 is His.
Dependencies are inferred from the claim text.