Human G-protein coupled receptors
AssigneeHuman Genome Sciences, Inc.
InventorsYi Li, Steven M. Ruben
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Abstract
Two human G-Protein coupled receptor polypeptides and DNA (RNA) encoding each of such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the nucleic acid sequence of each of the G-protein coupled receptors.
Claims49
An isolated polynucleotide consisting of at least 150 contiguous nucleotides of SEQ ID NO:1.
An isolated polynucleotide which encodes a polypeptide consisting of at least 30 contiguous amino acids of SEQ ID NO:2.
An isolated polynucleotide comprising a nucleic acid which encodes amino acids 2 to 342 of SEQ ID NO:2.
An isolated polynucleotide comprising a nucleic acid which encodes amino acids 1 to 342 of SEQ ID NO:2.
An isolated polynucleotide which encodes a polypeptide consisting of at least 30 contiguous amino acids encoded by the cDNA contained in ATCC deposit No. 209003.
An isolated polynucleotide comprising a nucleic acid which encodes the polypeptide encoded by the human cDNA of ATCC deposit No.209003.
Dependencies are inferred from the claim text.