US 6,887,675 B1 · Tankyrase H, compositions involved in the cell cycle and methods of use

Abstract

The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

Claims10

Dependent claims

A method of screening for a bioactive agent capable of modulating PARP activity comprising the steps of:

contacting a candidate bioactive agent with a Tankyrase H (TaHo) protein in the presence of a source of ADP-ribose, wherein the TaHo protein is encoded by a nucleic acid having at least 90% identity to the nucleic acid sequence set forth in FIG. 1 (SEQ ID NO:1) or FIG. 2 (SEQ ID NO:2);
and
determining the amount of poly ADP-ribose produced by said TaHo protein.

Dependencies are inferred from the claim text.

Facts

Application

09/843,159Filed 25 Apr 2001 · continuation in part

Priority

25 Oct 1999

Granted

3 May 2005

Term ends

Not estimatedThe source records don’t support an estimate.

Classification5 codes

C12N 9/1077
Glycosyltransferases: pentosyltransferases
A61K 38/00
Medicinal preparations containing peptides
C12N 2310/111
Antisense: spanning the whole gene, or a large part of it
C12N
Microorganisms or enzymes

Family

Application09/427,154Parent of this continuation-in-part · filed 25 Oct 1999

Application09/696,668Parent of this continuation-in-part · filed 25 Oct 2000

US 6,589,725 B1Parent of this continuation-in-part · filed 8 Jul 2003

US 6,617,102 B1Parent of this continuation-in-part · filed 9 Sep 2003

US 6,887,675 B1This patent

From the US filing history. Foreign family members aren’t listed.

Tankyrase H, compositions involved in the cell cycle and methods of use

Life of this patent

Tankyrase H, compositions involved in the cell cycle and methods of use

Life of this patent

Abstract

Claims10