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US 6,887,673 B2Granted
Humanized antibodies against human 4-1BB
AssigneeBristol-Myers Squibb Company
InventorsMaria Jure Kunkel, Subinay Ganguly, Ralph Abraham, Diane L. Hollenbaugh, Jill Rillema, Barbara Thorne, Walter W. Shuford, Robert S. Mittler
Life of this patent
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Abstract
A humanized antibody that binds to human 4-1BB and that allows binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for treating cancer in a subject comprising administering a therapeutically effective amount of the antibody to said subject.
Claims5
An isolated antibody that comprises a light chain and a heavy chain, wherein:
- said heavy chain includes a CDR1 comprising amino acids 50 to 54 of SEQ ID NO:5, a CDR2 comprising amino acids 69 to 85 of SEQ ID NO:5, and a CDR3 comprising amino acids 118 to 122 of SEQ ID NO:5;
- and
- said light chain includes a CDR1 comprising amino acids 44 to 60 of SEQ ID NO:8, a CDR2 comprising amino acids 76 to 82 of SEQ ID NO:8, and a CDR3 comprising amino acids 115 to 123 of SEQ ID NO:8.
An isolated antibody that comprises the amino acid sequence of SEQ ID NO:5 and SEQ ID NO:8.
Dependencies are inferred from the claim text.