Anti-equine Fc epsilon receptor alpha chain antibodies and methods to detect IgE
AssigneeHeska Corporation
InventorsEric R. Weber, Catherine A. McCall
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Abstract
The present invention relates to equine Fc epsilon receptor alpha chain nucleic acid molecules, proteins encoded by such nucleic acid molecules, antibodies raised against such proteins, and inhibitors of such proteins. The present invention also includes methods to detect IgE using such proteins and antibodies. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to mediate Fc epsilon receptor-mediated biological responses.
Claims16
A method to detect IgE comprising:
- (a) contacting an isolated equine FcεRα molecule comprising an amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:7, SEQ ID NO:12 and amino acid sequences at least 95% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:7, and SEQ ID NO:12, wherein said molecule comprises an IgE binding domain and binds to IgE, with a putative IgE-containing composition under conditions suitable for formation of a FcεRα molecule:IgE complex;
- and
- (b) determining the presence of IgE by detecting said FcεRα molecule:IgE complex, the presence of said FcεRα molecule:IgE complex indicating the presence of IgE.
Dependencies are inferred from the claim text.