Streptococcus pneumoniae SP036 polynucleotides
AssigneeHuman Genome Sciences, Inc.
InventorsGil H. Choi, Charles A. Kunsch, Steven C. Barash, Patrick J. Dillion, Brian Dougherty, Michael R. Fannon, Craig A. Rosen
Life of this patent
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Abstract
The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneumoniae. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Streptococcus pneumoniae. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.
Claims43
An isolated polynucleotide consisting of a nucleic acid sequence encoding an amino acid sequence consisting of SEQ ID NO:56.
An isolated polynucleotide consisting of a nucleic acid sequence encoding an amino acid sequence consisting of a portion of the amino acid sequence of SEQ ID NO:56, wherein said portion is selected from the group consisting of
- (a) Arg-10 to Arg-17;
- (b) Lys-29 to Ser-39;
- (c) Ser-140 to Ala-153,
- (d) Arg-158 to Tyr-169;
- (e) Asp-175 to Ala-183;
- (f) Gly-216 to Asn-236;
- (g) Ala-261 to Leu-270;
- (h) Arg-282 to Phe-291;
- (i) Thr-297 to Ala-305;
- (j) Pro-342 to Gln-362;
- (k) Phe-455 to Asp-463;
- (l) His-497 to Thr-517;
- (m) Ala-521 to Gly-529;
- (n) Ile-537 to Val-546;
- (o) Ile-556 to Ala-568;
- (p) Pro-581 to Ser-595;
- (q) Glu-670 to Ala-685;
- (r) Ser-696 to Ala-705;
- and
- (s) Leu-782 to Ser-791.
An isolated polynucleotide consisting of a nucleic acid sequence encoding an amino acid sequence consisting of a portion of SEQ ID NO:56, wherein said portion is at least 30 contiguous amino acid residues in length.
An isolated polynucleotide consisting of a nucleic acid molecule selected from the group consisting of:
- (a) SEQ ID NO:55;
- and
- (b) the full complement of (a).
An isolated polynucleotide consisting of at least 50 contiguous nucleotides of a nucleic acid sequence selected from the group consisting of:
- (a) SEQ ID NO:55;
- and
- (b) the full complement of (a).
Dependencies are inferred from the claim text.