Urinary assay for measuring bone resorption
AssigneeWashington Research Foundation
InventorDavid R. Eyre
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Abstract
A method for assaying bone resorption rates which consists of quantitating the concentration of peptide fragments derived from bone collagen, found in a body fluid is disclosed. The method includes immunometric assay, fluorometric assay and electrochemical titration. The structure of specific peptide fragments having 3-hydroxypyridinium cross-links found in urine of Paget's disease patients and procedures for making monoclonal antibodies is described.
Claims5
A method for determining the absolute rate of bone resorption, which comprises quantitating the concentration of peptide fragments in a body fluid, the peptide fragments being derived from bone collagen resorption and having a 3-hydroxypyridinium cross-link.
Dependencies are inferred from the claim text.