Nano-calcium phosphates/collagen based bone substitute materials
AssigneeTsinghua University
InventorsFuzhai Cui, Shuming Zhang, Wei Zhang, Qiang Cai, Qingling Feng
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Abstract
The present invention relates to a nano-calcium phosphates/collagen composite that mimics the natural bone, both in composition and microstructure, as well as porous bone substitute and tissue engineering scaffolds made by a complex of said composite and poly(lactic acid)(PLA) or poly(lactic acid-co-glycolic acid)(PLGA). The invention also relates to the use of said scaffold in treating bone defect and bone fracture.
Claims10
A nano-calcium phosphate/collagen composite, comprising collagen molecules and nano-calcium phosphate, wherein said composite comprises agglomerated particles having a diameter of 5-50 microns, wherein the agglomerated particles comprise a multiple laminar structure having periodically repeated units, each periodically repeated unit having a thickness of 10-15 nm and consisting of a layer of calcium phosphates and a layer of collagen.
Dependencies are inferred from the claim text.