Antigenic iron repressible proteins from N. meningitidis related to the hemolysin family of toxins
AssigneeThe University of North Carolina at Chapel Hill
InventorsP. Frederick Sparling, Stuart Thompson
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Abstract
An isolated, antigenic polypeptide comprises a segment having at least fifty amino acid residues. The amino acid sequence of the segment is present in N. meningitidis, and is different from, but substantially homologous with, the amino acid sequence of a segment of a member of the hemolysin family of toxins.
Claims12
An isolated N.meningitidis polypeptide comprising an amino acid sequence which is at least 90% identical to SEQ ID No:
- 2 and wherein antibodies against the polypeptide cross-react with alpha-hemolysin of E.coli or adenylate cyclase of B.pertussis.
A method of inducing antibodies against an N.meningitidis polypeptide in a mammal comprising administering to the mammal a composition that comprises an N.meningitidis polypeptide which comprises an amino acid sequence which is at least 90% identical to SEQ ID No:
- 2.
An immunogenic fragment of an N.meningitidis polypeptide which fragment comprises amino acid residues 763 to 789 of SEQ ID No:
- 2 and wherein antibodies against the fragment cross-react with alpha-hemolysin of E.coli or adenylate cyclase of B.pertussis.
A method of inducing antibodies against an N.meningitidis polypeptide in a mammal comprising administering to the mammal a composition that comprises an immunogenic fragment of an N.meningitidis polypeptide which fragment comprises amino acid residues 763 to 789 of SEQ ID No:
- 2.
An isolated polypeptide encoded by SEQ ID No:
- 1.
An immunogenic fragment of an N.meningitidis polypeptide which fragment comprises amino acid residues 900 to 989 of SEQ ID No:
- 2 and wherein antibodies against the fragment cross-react with alpha-hemolysin of E.coli or adenylate cyclase of B.pertussis.
A method of inducing antibodies against an N.meningitidis polypeptide in a mammal comprising administering to the mammal a composition that comprises an immunogenic fragment of an N.meningitidis potypeptide which fragment comprises amino acid residues 900 to 989 of SEQ ID No:
- 2.
Dependencies are inferred from the claim text.