Attenuated recombinant rabies virus mutants and live vaccines thereof
AssigneeAkzo Nobel N.V.
InventorTeshome Mebatsion
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Abstract
The present invention describes recombinant RV mutants comprising a combine mutation in two different parts of the viral genome, involving the P and the G genes. The mutations in the P gene preferably encompass residues 139 to 170, more preferably residue 139 to 149, most preferably residues 143-149. The mutation can be a substitution or deletion of one or more amino acids in the above region, as well as combinations of deletion and substitution.
Claims18
A recombinant rabies virus mutant comprising a mutation in the G protein and a mutation in the P protein, which mutation in the P protein is a deletion comprising the amino acids at positions 143 to 149.
A recombinant rabies virus mutant comprising a mutation in the G protein and a mutation one or more of the amino acids at positions 143 to 149 and 139 to 149 in the P protein.
Dependencies are inferred from the claim text.