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US 6,887,474 B1Granted
Compositions and methods for producing vascular occlusion
AssigneeViRexx Medical Corp.
InventorsMichael William Stewart, Roland Henryk Person, Antoine Noujaim
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Abstract
The present invention relates generally to methods and compositions for targeting, delivering, and activating platelet-dependent vascular occlusion agents. In particular, antibodies carrying platelet binding agents are targeted to hyperplastic cells or tissues, such as the vasculature of solid tumor masses; the platelet binding agent then binds and activates platelets, which in turn bind and activate other platelets. This process results in the formation of a platelet-mediated thrombus-causing vessel occlusion.
Claims5
A method of inducing a thrombus in vivo comprising:
- administering a first agent that is a binding agent having
- a) a first component comprising an antibody or an antigen binding portion thereof that binds to a pre-selected site selected from the group consisting of tumor-associated antigens and tumor-specific antigens and
- b) a second component comprising a first ligand;
- administering an anti-ligand that specifically binds to the first ligand;
- administering a second agent that specifically binds to platelets, the second agent comprising von Willebrand factor and a second ligand that specifically binds to the anti-ligand;
- and
- binding platelets on the second agent and inducing activation of the platelets;
- thereby inducing a thrombus in vivo, wherein the first and second ligands and the anti-ligand consist of a complementary set of molecules that specifically bind to each other and are selected from the group consisting of biotin/avidin, zinc finger protein/dsDNA fragment, enzyme/inhibitor, hapten/antibody, ligand/receptor, homophylic peptides and leucine zipper sets.
5 more elements
Dependencies are inferred from the claim text.