Method to inhibit T cell interactions with soluble B7
AssigneeBristol-Myers Squibb Company
InventorsPeter S. Linsley, Jeffrey A. Ledbetter, Nitin K. Damle, William Brady
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Abstract
This invention provides methods for regulating T cell interactions with B7 positive cells. Methods are provided for using B7 antigen, its fragments and derivatives reactive with CTLA4 receptor, to regulate CTLA4 positive T cell responses, and immune responses mediated by T cells.
Claims5
A method for inhibiting functional CTLA4 positive T cell interactions with B7 positive cells comprising contacting the CTLA positive cells with a ligand for CTLA4, in an amount effective to interfere with reaction of endogenous B7 antigen with the CTLA4 positive cells, wherein the ligand for CTLA4 is a soluble B7 comprising the extracellular domain of B7 having the sequence disclosed in SEQ ID NO:23.
Dependencies are inferred from the claim text.